Jared T. Hammill, PhD
Assistant Professor

Dr. Hammill is a Assistant Research Professor working with Dean Guy in the College of Pharmacy at the University of Kentucky. Dr. Hammill obtained his BA in chemistry from Franklin and Marshall College in Lancaster, PA in 2007. While in college, Dr. Hammill got his first taste of research working as a Howard Hughes Medical Institute Undergraduate Summer Research Scholar with Professor Ryan Mehl, using site-specific incorporation of unnatural amino acids and Fluorine NMR to probe protein structure and reactivity.  In 2012, he received his PhD in organic chemistry under the mentorship of Dr. Peter Wipf at the University of Pittsburgh. His doctoral work focused on the chemical syntheses of peptidic, natural product inspired, and heterocyclic small molecules. From 2013 to 2016, he worked as a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Post-Doctoral Fellow under the guidance of Drs. R. Kip Guy and Brenda A. Schulman at St. Jude Children’s Research Hospital. During is postdoctoral studies, Dr. Hammill refined his skills as a synthetic chemist while learning how to incorporate in vitro and in vivo toxicology, pharmacokinetics studies, and cell biology into the drug discovery process. In late 2016, he accepted his current role, moving with Dean Guy to the University of Kentucky to assist with strategic planning, scientific writing, budget management, and trainee oversight, while continuing to support synthetic chemistry efforts. In 2020, Dr. Hammill was promoted to Assistant Research Professor within the department of pharmaceutical sciences. Dr. Hammill’s diverse research experience in both synthetic organic chemistry and molecular biology has instilled in him a passion to solve complex, biologically relevant, synthetic problems through constant self-education, hard work, and collaborations with other researchers.  His primary research interests focus on using synthetic chemistry to probe the effects of protein-protein interactions and post-translational modifications on the progression of cancer and other catastrophic diseases. He is the author of 20 papers and the inventor on 2 issued patents.


Google Scholar

Updated 07/01/2021

1.Antimalarial Activity of 2,6-Dibenzylidenecyclohexanone Derivatives. Eagon S, Hammill JT, Fitzsimmons K, Sienko N, Nguyen B, Law J, Manjunath A, Wilkinson SP, Thompson K, Elizabeth Glidden J, Rice AL, Falade MO, Kimball JJ, DiBernardo C, Kiplin Guy R. Bioorg Med Chem Lett. 2021 Jun 19:128216. doi: 10.1016/j.bmcl.2021.128216. Online ahead of print. PMID: 34157390
2.Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. Kim HS, Hammill JT, Scott DC, Chen Y, Rice AL, Pistel W, Singh B, Schulman BA, Guy RK. J Med Chem. 2021 May 13;64(9):5850-5862. doi: 10.1021/acs.jmedchem.1c00035. Epub 2021 May 4. PMID: 33945681
3.Identification of Plasmodium falciparum heat shock 90 inhibitors via molecular docking. Everson N, Bach J, Hammill JT, Falade MO, Rice AL, Guy RK, Eagon S. Bioorg Med Chem Lett. 2021 Mar 1;35:127818. doi: 10.1016/j.bmcl.2021.127818. Epub 2021 Jan 26. PMID: 33513390
4.Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials. Barrows RD, Hammill JT, Tran MC, Falade MO, Rice AL, Davis CW, Emge TJ, Rablen PR, Kiplin Guy R, Knapp S. Bioorg Med Chem. 2020 Nov 15;28(22):115758. doi: 10.1016/j.bmc.2020.115758. Epub 2020 Sep 11. PMID: 33007559
5.Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines. Eagon S, Hammill JT, Sigal M, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice AL, Falade MO, Takahashi R, Kim K, Cheung A, DiBernardo C, Kimball JJ, Winzeler EA, Eribez K, Mittal N, Gamo FJ, Crespo B, Churchyard A, García-Barbazán I, Baum J, Anderson MO, Laleu B, Guy RK. J Med Chem. 2020 Oct 22;63(20):11902-11919. doi: 10.1021/acs.jmedchem.0c01152. Epub 2020 Oct 1. PMID: 32945666
6.Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein. Eagon S, Hammill JT, Bach J, Everson N, Sisley TA, Walls MJ, Durham S, Pillai DR, Falade MO, Rice AL, Kimball JJ, Lazaro H, DiBernardo C, Kiplin Guy R. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127502. doi: 10.1016/j.bmcl.2020.127502. Epub 2020 Aug 18. PMID: 32822760
7.Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Kim HS, Hammill JT, Scott DC, Chen Y, Min J, Rector J, Singh B, Schulman BA, Guy RK. J Med Chem. 2019 Sep 26;62(18):8429-8442. doi: 10.1021/acs.jmedchem.9b00410. Epub 2019 Sep 13. PMID: 31465221 Free PMC article.
8.Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK. J Med Chem. 2018 Apr 12;61(7):2680-2693. doi: 10.1021/acs.jmedchem.7b01277. Epub 2018 Mar 26. PMID: 29547696 Free PMC article.
9.Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26. PMID: 29547693 Free PMC article.
10.Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM. PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec. PMID: 29287089 Free PMC article.
11.Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA, Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J, Singh B, Harper JW, Schulman BA, Guy RK. Nat Chem Biol. 2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. PMID: 28581483 Free PMC article.
12.Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). Kim HS, Hammill JT, Guy RK. J Med Chem. 2017 Apr 13;60(7):2651-2653. doi: 10.1021/acs.jmedchem.7b00299. Epub 2017 Mar 15. PMID: 28296396
13.Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Keffer JL, Huecas S, Hammill JT, Wipf P, Andreu JM, Bewley CA. Bioorg Med Chem. 2013 Sep 15;21(18):5673-8. doi: 10.1016/j.bmc.2013.07.033. Epub 2013 Jul 25. PMID: 23932448 Free PMC article.
14.Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Keffer JL, Hammill JT, Lloyd JR, Plaza A, Wipf P, Bewley CA. Mar Drugs. 2012 May;10(5):1103-25. doi: 10.3390/md10051103. Epub 2012 May 22. PMID: 22822360 Free PMC article.
15.Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. Hammill JT, Contreras-García J, Virshup AM, Beratan D, Yang W, Wipf P. Tetrahedron. 2010 Mar 31;66(31):5852-5862. doi: 10.1016/j.tet.2010.04.112. PMID: 20798897 Free PMC article.
16.Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT. PLoS One. 2010 Jun 30;5(6):e11378. doi: 10.1371/journal.pone.0011378. PMID: 20614028 Free PMC article.
17.Generating permissive site-specific unnatural aminoacyl-tRNA synthetases. Miyake-Stoner SJ, Refakis CA, Hammill JT, Lusic H, Hazen JL, Deiters A, Mehl RA. Biochemistry. 2010 Mar 2;49(8):1667-77. doi: 10.1021/bi901947r. PMID: 20082521
18.Probing protein folding using site-specifically encoded unnatural amino acids as FRET donors with tryptophan. Miyake-Stoner SJ, Miller AM, Hammill JT, Peeler JC, Hess KR, Mehl RA, Brewer SH. Biochemistry. 2009 Jun 30;48(25):5953-62. doi: 10.1021/bi900426d. PMID: 19492814
19.Preparation of site-specifically labeled fluorinated proteins for 19F-NMR structural characterization. Hammill JT, Miyake-Stoner S, Hazen JL, Jackson JC, Mehl RA. Nat Protoc. 2007;2(10):2601-7. doi: 10.1038/nprot.2007.379. PMID: 17948003
20.Site-specific incorporation of a (19)F-amino acid into proteins as an NMR probe for characterizing protein structure and reactivity. Jackson JC, Hammill JT, Mehl RA. J Am Chem Soc. 2007 Feb 7;129(5):1160-6. doi: 10.1021/ja064661t. PMID: 17263397