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Listed from 07/01/2021
| 1. | Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. Kim HS, Hammill JT, Scott DC, Chen Y, Rice AL, Pistel W, Singh B, Schulman BA, Guy RK. J Med Chem. 2021 May 13;64(9):5850-5862. doi: 10.1021/acs.jmedchem.1c00035. Epub 2021 May 4. PMID: 33945681 |
| 2. | Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones. Chen Y, Zhu F, Hammill J, Holbrook G, Yang L, Freeman B, White KL, Shackleford DM, O’Loughlin KG, Charman SA, Mirsalis JC, Guy RK. Malar J. 2021 Feb 19;20(1):107. doi: 10.1186/s12936-021-03617-1. PMID: 33608015 Free PMC article. |
| 3. | Identification of Plasmodium falciparum heat shock 90 inhibitors via molecular docking. Everson N, Bach J, Hammill JT, Falade MO, Rice AL, Guy RK, Eagon S. Bioorg Med Chem Lett. 2021 Mar 1;35:127818. doi: 10.1016/j.bmcl.2021.127818. Epub 2021 Jan 26. PMID: 33513390 |
| 4. | Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines. Eagon S, Hammill JT, Sigal M, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice AL, Falade MO, Takahashi R, Kim K, Cheung A, DiBernardo C, Kimball JJ, Winzeler EA, Eribez K, Mittal N, Gamo FJ, Crespo B, Churchyard A, García-Barbazán I, Baum J, Anderson MO, Laleu B, Guy RK. J Med Chem. 2020 Oct 22;63(20):11902-11919. doi: 10.1021/acs.jmedchem.0c01152. Epub 2020 Oct 1. PMID: 32945666 |
| 5. | University-pharmacy partnerships for COVID-19. Venditto VJ, Hudspeth B, Freeman PR, Kebodeaux C, Guy RK. Science. 2020 Sep 18;369(6510):1441. doi: 10.1126/science.abe3339. PMID: 32943518 No abstract available. |
| 6. | Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer. Slavish PJ, Chi L, Yun MK, Tsurkan L, Martinez NE, Jonchere B, Chai SC, Connelly M, Waddell MB, Das S, Neale G, Li Z, Shadrick WR, Olsen RR, Freeman KW, Low JA, Price JE, Young BM, Bharatham N, Boyd VA, Yang J, Lee RE, Morfouace M, Roussel MF, Chen T, Savic D, Guy RK, White SW, Shelat AA, Potter PM. Cancer Res. 2020 Sep 1;80(17):3507-3518. doi: 10.1158/0008-5472.CAN-19-3934. Epub 2020 Jul 10. PMID: 32651255 Free PMC article. |
| 7. | Rapid repurposing of drugs for COVID-19. Guy RK, DiPaola RS, Romanelli F, Dutch RE. Science. 2020 May 22;368(6493):829-830. doi: 10.1126/science.abb9332. Epub 2020 May 8. PMID: 32385101 No abstract available. |
| 8. | Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. Gaur AH, McCarthy JS, Panetta JC, Dallas RH, Woodford J, Tang L, Smith AM, Stewart TB, Branum KC, Freeman BB 3rd, Patel ND, John E, Chalon S, Ost S, Heine RN, Richardson JL, Christensen R, Flynn PM, Van Gessel Y, Mitasev B, Möhrle JJ, Gusovsky F, Bebrevska L, Guy RK. Lancet Infect Dis. 2020 Aug;20(8):964-975. doi: 10.1016/S1473-3099(19)30611-5. Epub 2020 Apr 8. PMID: 32275867 Clinical Trial. |
| 9. | Report of the 2018-2019 Research and Graduate Affairs Committee. O’Donnell JM, Anand S, Brown SD, Fuji KT, Guy RK, Kawaguchi-Suzuki M, Meier KE, Nelson CE, Vyas A, Block KF, Farrell DF. Am J Pharm Educ. 2019 Dec;83(10):7595. doi: 10.5688/ajpe7595. PMID: 32001891 Free PMC article. |
| 10. | Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Kim HS, Hammill JT, Scott DC, Chen Y, Min J, Rector J, Singh B, Schulman BA, Guy RK. J Med Chem. 2019 Sep 26;62(18):8429-8442. doi: 10.1021/acs.jmedchem.9b00410. Epub 2019 Sep 13. PMID: 31465221 Free PMC article. |
| 11. | Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein D, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. ACS Chem Biol. 2019 Jul 19;14(7):1673. doi: 10.1021/acschembio.9b00488. Epub 2019 Jun 28. PMID: 31251562 No abstract available. |
| 12. | A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML. Drenberg CD, Shelat A, Dang J, Cotton A, Orwick SJ, Li M, Jeon JY, Fu Q, Buelow DR, Pioso M, Hu S, Inaba H, Ribeiro RC, Rubnitz JE, Gruber TA, Guy RK, Baker SD. Nat Commun. 2019 May 16;10(1):2189. doi: 10.1038/s41467-019-09917-0. PMID: 31097698 Free PMC article. |
| 13. | Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis. Colon BL, Rice CA, Guy RK, Kyle DE. J Infect Dis. 2019 Mar 15;219(7):1095-1103. doi: 10.1093/infdis/jiy622. PMID: 30358879 Free PMC article. |
| 14. | Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Häcker H. Sci Signal. 2018 Aug 14;11(543):eaaq1077. doi: 10.1126/scisignal.aaq1077. PMID: 30108181 Free PMC article. |
| 15. | Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Biosci Rep. 2018 Jul 6;38(4):BSR20180231_COR. doi: 10.1042/BSR20180231_COR. Print 2018 Aug 31. PMID: 29871975 Free PMC article. No abstract available. |
| 16. | A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships. Mathew B, Snowden TS, Connelly MC, Guy RK, Reynolds RC. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2136-2142. doi: 10.1016/j.bmcl.2018.05.023. Epub 2018 May 10. PMID: 29776741 Free PMC article. |
| 17. | Oxazole and thiazole analogs of sulindac for cancer prevention. Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC. Future Med Chem. 2018 Apr 1;10(7):743-753. doi: 10.4155/fmc-2017-0182. Epub 2018 Apr 19. PMID: 29671617 Free PMC article. |
| 18. | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK. J Med Chem. 2018 Apr 12;61(7):2680-2693. doi: 10.1021/acs.jmedchem.7b01277. Epub 2018 Mar 26. PMID: 29547696 Free PMC article. |
| 19. | Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26. PMID: 29547693 Free PMC article. |
| 20. | CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. Teitz T, Fang J, Goktug AN, Bonga JD, Diao S, Hazlitt RA, Iconaru L, Morfouace M, Currier D, Zhou Y, Umans RA, Taylor MR, Cheng C, Min J, Freeman B, Peng J, Roussel MF, Kriwacki R, Guy RK, Chen T, Zuo J. J Exp Med. 2018 Apr 2;215(4):1187-1203. doi: 10.1084/jem.20172246. Epub 2018 Mar 7. PMID: 29514916 Free PMC article. |
| 21. | Amine Containing Analogs of Sulindac for Cancer Prevention. Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC. Open Med Chem J. 2018 Jan 31;12:1-12. doi: 10.2174/1874104501812010001. eCollection 2018. PMID: 29492166 Free PMC article. |
| 22. | Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Print 2018 Aug 31. PMID: 29472314 Free PMC article. |
| 23. | Establishing a Preclinical Multidisciplinary Board for Brain Tumors. Nimmervoll BV, Boulos N, Bianski B, Dapper J, DeCuypere M, Shelat A, Terranova S, Terhune HE, Gajjar A, Patel YT, Freeman BB, Onar-Thomas A, Stewart CF, Roussel MF, Guy RK, Merchant TE, Calabrese C, Wright KD, Gilbertson RJ. Clin Cancer Res. 2018 Apr 1;24(7):1654-1666. doi: 10.1158/1078-0432.CCR-17-2168. Epub 2018 Jan 4. PMID: 29301833 Free PMC article. |
| 24. | Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM. PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec. PMID: 29287089 Free PMC article. |
| 25. | Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein D, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. ACS Chem Biol. 2017 Sep 15;12(9):2436-2447. doi: 10.1021/acschembio.7b00527. Epub 2017 Aug 29. PMID: 28787124 Free PMC article. |
| 26. | Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Cancer Res. 2017 Sep 1;77(17):4626-4638. doi: 10.1158/0008-5472.CAN-16-0826. Epub 2017 Jul 6. PMID: 28684529 Free PMC article. |
| 27. | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA, Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J, Singh B, Harper JW, Schulman BA, Guy RK. Nat Chem Biol. 2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. PMID: 28581483 Free PMC article. |
| 28. | Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. Jarusiewicz JA, Jeon JY, Connelly MC, Chen Y, Yang L, Baker SD, Guy RK. ACS Omega. 2017 May 31;2(5):1985-2009. doi: 10.1021/acsomega.7b00144. Epub 2017 May 10. PMID: 28580438 Free PMC article. |
| 29. | Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx. Bharatham N, Finch KE, Min J, Mayasundari A, Dyer MA, Guy RK, Bashford D. J Mol Graph Model. 2017 Jun;74:54-60. doi: 10.1016/j.jmgm.2017.02.014. Epub 2017 Feb 24. PMID: 28351017 Free PMC article. |
| 30. | Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). Kim HS, Hammill JT, Guy RK. J Med Chem. 2017 Apr 13;60(7):2651-2653. doi: 10.1021/acs.jmedchem.7b00299. Epub 2017 Mar 15. PMID: 28296396 |
| 31. | Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition. Verras A, Waller CL, Gedeck P, Green DV, Kogej T, Raichurkar A, Panda M, Shelat AA, Clark J, Guy RK, Papadatos G, Burrows J. J Chem Inf Model. 2017 Mar 27;57(3):445-453. doi: 10.1021/acs.jcim.6b00572. Epub 2017 Mar 17. PMID: 28257198 |
| 32. | Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH. ACS Cent Sci. 2016 Oct 26;2(10):687-701. doi: 10.1021/acscentsci.6b00086. Epub 2016 Sep 14. PMID: 27800551 Free PMC article. |
| 33. | Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. Mathew B, Hobrath JV, Ross L, Connelly MC, Lofton H, Rajagopalan M, Guy RK, Reynolds RC. PLoS One. 2016 Oct 21;11(10):e0164100. doi: 10.1371/journal.pone.0164100. eCollection 2016. PMID: 27768711 Free PMC article. |
| 34. | Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins. Danelius E, Pettersson M, Bred M, Min J, Waddell MB, Guy RK, Grøtli M, Erdelyi M. Org Biomol Chem. 2016 Nov 8;14(44):10386-10393. doi: 10.1039/c6ob01510g. PMID: 27731454 |
| 35. | Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides. Floyd DM, Stein P, Wang Z, Liu J, Castro S, Clark JA, Connelly M, Zhu F, Holbrook G, Matheny A, Sigal MS, Min J, Dhinakaran R, Krishnan S, Bashyum S, Knapp S, Guy RK. J Med Chem. 2016 Sep 8;59(17):7950-62. doi: 10.1021/acs.jmedchem.6b00752. Epub 2016 Aug 25. PMID: 27505686 Free PMC article. |
| 36. | Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D’Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul. PMID: 27467575 Free PMC article. |
| 37. | Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum. Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, Twarog N, Shelat AA, Walker LA, Muhammad I, Guy RK. Malar J. 2016 May 10;15(1):270. doi: 10.1186/s12936-016-1313-7. PMID: 27165106 Free PMC article. |
| 38. | Evaluation of artemisinins for the treatment of acute myeloid leukemia. Drenberg CD, Buaboonnam J, Orwick SJ, Hu S, Li L, Fan Y, Shelat AA, Guy RK, Rubnitz J, Baker SD. Cancer Chemother Pharmacol. 2016 Jun;77(6):1231-43. doi: 10.1007/s00280-016-3038-2. Epub 2016 Apr 28. PMID: 27125973 Free PMC article. |
| 39. | Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes. Bruhn DF, Wyllie S, Rodríguez-Cortés A, Carrillo AK, Rakesh, Guy RK, Fairlamb AH, Lee RE. J Antimicrob Chemother. 2016 Apr;71(4):956-63. doi: 10.1093/jac/dkv417. Epub 2015 Dec 18. PMID: 26682963 Free PMC article. |
| 40. | Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. Min J, Guo K, Suryadevara PK, Zhu F, Holbrook G, Chen Y, Feau C, Young BM, Lemoff A, Connelly MC, Kastan MB, Guy RK. J Med Chem. 2016 Jan 28;59(2):559-77. doi: 10.1021/acs.jmedchem.5b01092. Epub 2016 Jan 12. PMID: 26632965 |
| 41. | Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction. Pettersson M, Quant M, Min J, Iconaru L, Kriwacki RW, Waddell MB, Guy RK, Luthman K, Grøtli M. PLoS One. 2015 Oct 1;10(10):e0137867. doi: 10.1371/journal.pone.0137867. eCollection 2015. PMID: 26427060 Free PMC article. |
| 42. | LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia. Ravu RR, Jacob MR, Jeffries C, Tu Y, Khan SI, Agarwal AK, Guy RK, Walker LA, Clark AM, Li XC. J Nat Prod. 2015 Sep 25;78(9):2255-9. doi: 10.1021/acs.jnatprod.5b00470. Epub 2015 Sep 15. PMID: 26371504 |
| 43. | Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia. Churchman ML, Low J, Qu C, Paietta EM, Kasper LH, Chang Y, Payne-Turner D, Althoff MJ, Song G, Chen SC, Ma J, Rusch M, McGoldrick D, Edmonson M, Gupta P, Wang YD, Caufield W, Freeman B, Li L, Panetta JC, Baker S, Yang YL, Roberts KG, McCastlain K, Iacobucci I, Peters JL, Centonze VE, Notta F, Dobson SM, Zandi S, Dick JE, Janke L, Peng J, Kodali K, Pagala V, Min J, Mayasundari A, Williams RT, Willman CL, Rowe J, Luger S, Dickins RA, Guy RK, Chen T, Mullighan CG. Cancer Cell. 2015 Sep 14;28(3):343-56. doi: 10.1016/j.ccell.2015.07.016. Epub 2015 Aug 27. PMID: 26321221 Free PMC article. |
| 44. | Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma. Pritchard EM, Dyer MA, Guy RK. Mini Rev Med Chem. 2016;16(6):430-54. doi: 10.2174/1389557515666150722100610. PMID: 26202204 Free PMC article. Review. |
| 45. | Coastal Vertebrate Exposure to Predicted Habitat Changes Due to Sea Level Rise. Hunter EA, Nibbelink NP, Alexander CR, Barrett K, Mengak LF, Guy RK, Moore CT, Cooper RJ. Environ Manage. 2015 Dec;56(6):1528-37. doi: 10.1007/s00267-015-0580-3. Epub 2015 Jul 11. PMID: 26163199 |
| 46. | 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction. Pettersson M, Bliman D, Jacobsson J, Nilsson JR, Min J, Iconaru L, Guy RK, Kriwacki RW, Andréasson J, Grøtli M. PLoS One. 2015 May 5;10(5):e0124423. doi: 10.1371/journal.pone.0124423. eCollection 2015. PMID: 25942498 Free PMC article. |
| 47. | NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. Nat Genet. 2015 Jun;47(6):607-14. doi: 10.1038/ng.3283. Epub 2015 May 4. PMID: 25938942 Free PMC article. |
| 48. | Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds. Ortiz D, Guiguemde WA, Johnson A, Elya C, Anderson J, Clark J, Connelly M, Yang L, Min J, Sato Y, Guy RK, Landfear SM. PLoS One. 2015 Apr 20;10(4):e0123598. doi: 10.1371/journal.pone.0123598. eCollection 2015. PMID: 25894322 Free PMC article. |
| 49. | Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Carrillo AK, Guiguemde WA, Guy RK. Bioorg Med Chem. 2015 Aug 15;23(16):5151-5. doi: 10.1016/j.bmc.2014.12.066. Epub 2015 Jan 2. PMID: 25637120 |
| 50. | Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen. Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC. Antimicrob Agents Chemother. 2015 Mar;59(3):1389-97. doi: 10.1128/AAC.01930-13. Epub 2014 Dec 15. PMID: 25512421 Free PMC article. |
| 51. | (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O’Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gómez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martínez MS, Miller G, Rodríguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62. doi: 10.1073/pnas.1414221111. Epub 2014 Dec 1. PMID: 25453091 Free PMC article. |
| 52. | Antimalarials in development in 2014. Barnett DS, Guy RK. Chem Rev. 2014 Nov 26;114(22):11221-41. doi: 10.1021/cr500543f. Epub 2014 Oct 23. PMID: 25340626 Review. No abstract available. |
| 53. | Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition. Vara BA, Mayasundari A, Tellis JC, Danneman MW, Arredondo V, Davis TA, Min J, Finch K, Guy RK, Johnston JN. J Org Chem. 2014 Aug 1;79(15):6913-38. doi: 10.1021/jo501003r. Epub 2014 Jul 14. PMID: 25017623 Free PMC article. |
| 54. | Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses. Guiguemde WA, Hunt NH, Guo J, Marciano A, Haynes RK, Clark J, Guy RK, Golenser J. Antimicrob Agents Chemother. 2014 Aug;58(8):4745-54. doi: 10.1128/AAC.01553-13. Epub 2014 Jun 9. PMID: 24913162 Free PMC article. |
| 55. | Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma. Pritchard EM, Stewart E, Zhu F, Bradley C, Griffiths L, Yang L, Suryadevara PK, Zhang J, Freeman BB 3rd, Guy RK, Dyer MA. Pharm Res. 2014 Nov;31(11):3060-72. doi: 10.1007/s11095-014-1399-y. Epub 2014 Jun 7. PMID: 24906597 Free PMC article. |
| 56. | Repositioning: the fast track to new anti-malarial medicines? Lotharius J, Gamo-Benito FJ, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, Parkinson T, Viswanath P, Bandodkar B, Rautela N, Bharath S, Duffy S, Avery VM, Möhrle JJ, Guy RK, Wells T. Malar J. 2014 Apr 14;13:143. doi: 10.1186/1475-2875-13-143. PMID: 24731288 Free PMC article. |
| 57. | Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF, Keiser J, Vennerstrom JL. Am J Trop Med Hyg. 2014 Jun;90(6):1156-8. doi: 10.4269/ajtmh.14-0029. Epub 2014 Mar 31. PMID: 24686741 Free PMC article. |
| 58. | Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Morfouace M, Shelat A, Jacus M, Freeman BB 3rd, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, Guy RK, Stewart CF, Gajjar A, Roussel MF. Cancer Cell. 2014 Apr 14;25(4):516-29. doi: 10.1016/j.ccr.2014.02.009. Epub 2014 Mar 27. PMID: 24684846 Free PMC article. |
| 59. | UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, Guy RK, Li XC. J Nat Prod. 2014 Apr 25;77(4):902-9. doi: 10.1021/np4009706. Epub 2014 Mar 11. PMID: 24617915 Free PMC article. |
| 60. | Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. Guo K, Shelat AA, Guy RK, Kastan MB. J Biomol Screen. 2014 Apr;19(4):538-46. doi: 10.1177/1087057113520325. Epub 2014 Jan 24. PMID: 24464432 |
| 61. | Anticancer properties of distinct antimalarial drug classes. Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. PLoS One. 2013 Dec 31;8(12):e82962. doi: 10.1371/journal.pone.0082962. eCollection 2013. PMID: 24391728 Free PMC article. |
| 62. | Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy J. Antimicrob Agents Chemother. 2014;58(3):1516-22. doi: 10.1128/AAC.02148-13. Epub 2013 Dec 23. PMID: 24366746 Free PMC article. |
| 63. | A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia. Singh H, Shelat AA, Singh A, Boulos N, Williams RT, Guy RK. J Biomol Screen. 2014 Jan;19(1):158-67. doi: 10.1177/1087057113501081. Epub 2013 Aug 29. PMID: 23989453 Free PMC article. |
| 64. | Quinolone-3-diarylethers: a new class of antimalarial drug. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CHM, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK. Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029. PMID: 23515079 Free PMC article. |
| 65. | Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. J Med Chem. 2013 Apr 11;56(7):2850-60. doi: 10.1021/jm301687p. Epub 2013 Mar 26. PMID: 23484493 |
| 66. | Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Hwang JY, Attia RR, Carrillo AK, Connelly MC, Guy RK. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1891-5. doi: 10.1016/j.bmcl.2012.12.055. Epub 2013 Jan 8. PMID: 23414840 Free PMC article. |
| 67. | Use of Anecdotal Occurrence Data in Species Distribution Models: An Example Based on the White-Nosed Coati (Nasua narica) in the American Southwest. Frey JK, Lewis JC, Guy RK, Stuart JN. Animals (Basel). 2013 Apr 17;3(2):327-48. doi: 10.3390/ani3020327. PMID: 26487405 Free PMC article. |
| 68. | Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening. Zhang L, Fourches D, Sedykh A, Zhu H, Golbraikh A, Ekins S, Clark J, Connelly MC, Sigal M, Hodges D, Guiguemde A, Guy RK, Tropsha A. J Chem Inf Model. 2013 Feb 25;53(2):475-92. doi: 10.1021/ci300421n. Epub 2013 Jan 23. PMID: 23252936 Free PMC article. |
| 69. | Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin. Cloete TT, Krebs HJ, Clark JA, Connelly MC, Orcutt A, Sigal MS, Guy RK, N’Da DD. Bioorg Chem. 2013 Feb;46:10-6. doi: 10.1016/j.bioorg.2012.10.002. Epub 2012 Nov 3. PMID: 23247255 |
| 70. | Lead optimization of antimalarial propafenone analogues. Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, Kyle DE, Mirsalis J, Guy RK. J Med Chem. 2012 Jul 12;55(13):6087-93. doi: 10.1021/jm300286a. Epub 2012 Jun 29. PMID: 22708838 Free PMC article. |
| 71. | An all-purpose antimalarial drug target. Guiguemde WA, Guy RK. Cell Host Microbe. 2012 Jun 14;11(6):555-7. doi: 10.1016/j.chom.2012.05.008. PMID: 22704614 Review. |
| 72. | On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4. PMID: 22675482 Free PMC article. |
| 73. | Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. J Med Chem. 2012 May 24;55(10):4640-51. doi: 10.1021/jm300460c. Epub 2012 May 16. PMID: 22563729 Free PMC article. |
| 74. | Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, Guy RK. J Med Chem. 2012 May 10;55(9):4205-19. doi: 10.1021/jm201642z. Epub 2012 Apr 18. PMID: 22435599 Free PMC article. |
| 75. | Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. Hwang JY, Attia RR, Zhu F, Yang L, Lemoff A, Jeffries C, Connelly MC, Guy RK. J Med Chem. 2012 Mar 8;55(5):2301-10. doi: 10.1021/jm201546m. Epub 2012 Feb 23. PMID: 22324546 Free PMC article. |
| 76. | Global phenotypic screening for antimalarials. Guiguemde WA, Shelat AA, Garcia-Bustos JF, Diagana TT, Gamo FJ, Guy RK. Chem Biol. 2012 Jan 27;19(1):116-29. doi: 10.1016/j.chembiol.2012.01.004. PMID: 22284359 Free PMC article. Review. |
| 77. | Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. Lack NA, Axerio-Cilies P, Tavassoli P, Han FQ, Chan KH, Feau C, LeBlanc E, Guns ET, Guy RK, Rennie PS, Cherkasov A. J Med Chem. 2011 Dec 22;54(24):8563-73. doi: 10.1021/jm201098n. Epub 2011 Nov 18. PMID: 22047606 Free PMC article. |
| 78. | Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Guo J, Guiguemde AW, Bentura-Marciano A, Clark J, Haynes RK, Chan WC, Wong HN, Hunt NH, Guy RK, Golenser J. Antimicrob Agents Chemother. 2012 Jan;56(1):163-73. doi: 10.1128/AAC.05006-11. Epub 2011 Oct 17. PMID: 22006004 Free PMC article. |
| 79. | Optimization of propafenone analogues as antimalarial leads. Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. J Med Chem. 2011 Nov 10;54(21):7477-85. doi: 10.1021/jm2005546. Epub 2011 Oct 10. PMID: 21955244 Free PMC article. |
| 80. | Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity. Hwang JY, Kawasuji T, Lowes DJ, Clark JA, Connelly MC, Zhu F, Guiguemde WA, Sigal MS, Wilson EB, Derisi JL, Guy RK. J Med Chem. 2011 Oct 27;54(20):7084-93. doi: 10.1021/jm200636z. Epub 2011 Sep 26. PMID: 21910466 Free PMC article. |
| 81. | An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. Cancer Cell. 2011 Sep 13;20(3):384-99. doi: 10.1016/j.ccr.2011.08.013. PMID: 21907928 Free PMC article. |
| 82. | Similarities and differences between two modes of antagonism of the thyroid hormone receptor. Sadana P, Hwang JY, Attia RR, Arnold LA, Neale G, Guy RK. ACS Chem Biol. 2011 Oct 21;6(10):1096-106. doi: 10.1021/cb200092v. Epub 2011 Aug 15. PMID: 21815645 Free PMC article. |
| 83. | An automated approach to efficiently reformat a large collection of compounds. Cui J, Chai SC, Shelat AA, Guy RK, Chen T. Curr Chem Genomics. 2011;5:42-7. doi: 10.2174/1875397301105010042. Epub 2011 Jul 22. PMID: 21804905 Free PMC article. |
| 84. | Ligand competition binding assay for the androgen receptor. Féau C, Arnold LA, Kosinski A, Guy RK. Methods Mol Biol. 2011;776:59-68. doi: 10.1007/978-1-61779-243-4_4. PMID: 21796520 |
| 85. | Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11878-83. doi: 10.1073/pnas.1105160108. Epub 2011 Jul 5. PMID: 21730179 Free PMC article. |
| 86. | A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. J Biomol Screen. 2011 Jul;16(6):618-27. doi: 10.1177/1087057111402199. Epub 2011 Apr 11. PMID: 21482722 Free PMC article. |
| 87. | Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. J Biol Chem. 2011 Apr 8;286(14):11895-908. doi: 10.1074/jbc.M110.200436. Epub 2011 Feb 14. PMID: 21321127 Free PMC article. |
| 88. | Evaluation of Diarylureas for Activity Against Plasmodium falciparum. Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, Liou AP, Webb TR, Derisi JL, Guy RK. ACS Med Chem Lett. 2010 Dec 9;1(9):460-465. doi: 10.1021/ml100083c. PMID: 21243104 Free PMC article. |
| 89. | Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK. Bioorg Med Chem. 2010 Dec 1;18(23):8302-9. doi: 10.1016/j.bmc.2010.09.073. Epub 2010 Oct 8. PMID: 21051236 |
| 90. | Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration. Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy RK, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Panetta JC, Boulos N, Stewart CF. Drug Metab Dispos. 2011 Jan;39(1):15-21. doi: 10.1124/dmd.110.035915. Epub 2010 Oct 14. PMID: 20947617 Free PMC article. |
| 91. | Chemical genetics of Plasmodium falciparum. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099. PMID: 20485428 Free PMC article. |
| 92. | Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. J Med Chem. 2010 May 13;53(9):3685-95. doi: 10.1021/jm100057h. PMID: 20361799 Free PMC article. |
| 93. | qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. Huang W, Johnson RL, Huang R, Wichterman J, Hwang JY, Guy RK. 2010 Mar 18 [updated 2011 Mar 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21735607 Free Books & Documents. Review. |
| 94. | Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. Smithson DC, Lee J, Shelat AA, Phillips MA, Guy RK. J Biol Chem. 2010 May 28;285(22):16771-81. doi: 10.1074/jbc.M109.081588. Epub 2010 Mar 10. PMID: 20220141 Free PMC article. |
| 95. | Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Zhang Y, Guiguemde WA, Sigal M, Zhu F, Connelly MC, Nwaka S, Guy RK. Bioorg Med Chem. 2010 Apr 1;18(7):2756-66. doi: 10.1016/j.bmc.2010.02.013. Epub 2010 Feb 11. PMID: 20206533 Free PMC article. |
| 96. | Podophyllotoxin analogues active versus Trypanosoma brucei. Uddin MJ, Smithson DC, Brown KM, Crews BC, Connelly M, Zhu F, Marnett LJ, Guy RK. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1787-91. doi: 10.1016/j.bmcl.2010.01.009. Epub 2010 Jan 11. PMID: 20129783 Free PMC article. |
| 97. | Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. Smithson DC, Shelat AA, Baldwin J, Phillips MA, Guy RK. Assay Drug Dev Technol. 2010 Apr;8(2):175-85. doi: 10.1089/adt.2009.0249. PMID: 20085486 Free PMC article. |
| 98. | Identification and characterization of the first small molecule inhibitor of MDMX. Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. PMID: 20080970 Free PMC article. |
| 99. | Structure-guided development of selective TbcatB inhibitors. Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p. PMID: 19769357 Free PMC article. |
| 100. | Chemical approaches to nuclear receptors in metabolism. Margolis RN, Moore DD, Willson TM, Guy RK. Sci Signal. 2009 Aug 4;2(82):mr5. doi: 10.1126/scisignal.282mr5. PMID: 19654413 Free PMC article. |
| 101. | Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription. Féau C, Arnold LA, Kosinski A, Zhu F, Connelly M, Guy RK. ACS Chem Biol. 2009 Oct 16;4(10):834-43. doi: 10.1021/cb900143a. PMID: 19645433 Free PMC article. |
| 102. | Inhibition of a viral enzyme by a small-molecule dimer disruptor. Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Nat Chem Biol. 2009 Sep;5(9):640-6. doi: 10.1038/nchembio.192. Epub 2009 Jul 26. PMID: 19633659 Free PMC article. |
| 103. | Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. J Med Chem. 2009 Jul 9;52(13):3892-901. doi: 10.1021/jm9002704. PMID: 19469546 Free PMC article. |
| 104. | Antimalarial activity of thiosemicarbazones and purine derived nitriles. Mallari JP, Guiguemde WA, Guy RK. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3546-9. doi: 10.1016/j.bmcl.2009.04.142. Epub 2009 May 5. PMID: 19447616 Free PMC article. |
| 105. | Non-competitive androgen receptor inhibition in vitro and in vivo. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7233-8. doi: 10.1073/pnas.0807282106. Epub 2009 Apr 10. PMID: 19363158 Free PMC article. |
| 106. | Quantification of the vitamin D receptor-coregulator interaction. Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Biochemistry. 2009 Feb 24;48(7):1454-61. doi: 10.1021/bi801874n. PMID: 19183053 Free PMC article. |
| 107. | A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors. Féau C, Arnold LA, Kosinski A, Guy RK. J Biomol Screen. 2009 Jan;14(1):43-8. doi: 10.1177/1087057108326662. PMID: 19171919 Free PMC article. |
| 108. | Synthesis and characterization of BODIPY-labeled colchicine. Arnold LA, Ranaivo P, Guy RK. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5867-70. doi: 10.1016/j.bmcl.2008.07.068. Epub 2008 Jul 20. PMID: 18684625 Free PMC article. |
| 109. | Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8. PMID: 18420405 Free PMC article. |
| 110. | A road less traveled by: exploring a decade of Ellman chemistry. Shelat AA, Guy RK. Bioorg Med Chem. 2009 Feb 1;17(3):1088-93. doi: 10.1016/j.bmc.2008.02.087. Epub 2008 Mar 4. PMID: 18343129 Free PMC article. |
| 111. | Partial acetylation of lysine residues improves intraprotein cross-linking. Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Anal Chem. 2008 Feb 15;80(4):951-60. doi: 10.1021/ac701636w. Epub 2008 Jan 18. PMID: 18201069 |
| 112. | Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. PMID: 18173229 |
| 113. | Interaction between the androgen receptor and a segment of its corepressor SHP. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Acta Crystallogr D Biol Crystallogr. 2007 Nov;63(Pt 11):1198-200. doi: 10.1107/S0907444907045702. Epub 2007 Oct 17. PMID: 18007036 |
| 114. | Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen. Mills NL, Shelat AA, Guy RK. J Biomol Screen. 2007 Oct;12(7):946-55. doi: 10.1177/1087057107306128. PMID: 17942787 |
| 115. | Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. PMID: 17941623 |
| 116. | Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. J Med Chem. 2007 Nov 1;50(22):5269-80. doi: 10.1021/jm070556y. Epub 2007 Oct 5. PMID: 17918822 Free PMC article. |
| 117. | A surface on the androgen receptor that allosterically regulates coactivator binding. Estébanez-Perpiñá E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16074-9. doi: 10.1073/pnas.0708036104. Epub 2007 Oct 2. PMID: 17911242 Free PMC article. |
| 118. | Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Mol Endocrinol. 2007 Dec;21(12):2919-28. doi: 10.1210/me.2007-0174. Epub 2007 Sep 6. PMID: 17823305 |
| 119. | Scaffold composition and biological relevance of screening libraries. Shelat AA, Guy RK. Nat Chem Biol. 2007 Aug;3(8):442-6. doi: 10.1038/nchembio0807-442. PMID: 17637770 |
| 120. | Reporting data from high-throughput screening of small-molecule libraries. Inglese J, Shamu CE, Guy RK. Nat Chem Biol. 2007 Aug;3(8):438-41. doi: 10.1038/nchembio0807-438. PMID: 17637769 |
| 121. | The interdependence between screening methods and screening libraries. Shelat AA, Guy RK. Curr Opin Chem Biol. 2007 Jun;11(3):244-51. doi: 10.1016/j.cbpa.2007.05.003. Epub 2007 May 23. PMID: 17524728 Review. |
| 122. | Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. Warhurst DC, Craig JC, Adagu IS, Guy RK, Madrid PB, Fivelman QL. Biochem Pharmacol. 2007 Jun 15;73(12):1910-26. doi: 10.1016/j.bcp.2007.03.011. Epub 2007 Mar 19. PMID: 17466277 |
| 123. | An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. Cancer Res. 2007 Jan 15;67(2):573-9. doi: 10.1158/0008-5472.CAN-06-2726. PMID: 17234765 |
| 124. | Inactivation of the p53 pathway in retinoblastoma. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Nature. 2006 Nov 2;444(7115):61-6. doi: 10.1038/nature05194. PMID: 17080083 |
| 125. | Design of a selective chemical probe for class I PDZ domains. Fujii N, Shelat A, Hall RA, Guy RK. Bioorg Med Chem Lett. 2007 Jan 15;17(2):546-8. doi: 10.1016/j.bmcl.2006.10.027. Epub 2006 Oct 17. PMID: 17074480 |
| 126. | Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. Bioorg Med Chem Lett. 2007 Jan 15;17(2):549-52. doi: 10.1016/j.bmcl.2006.10.006. Epub 2006 Oct 6. PMID: 17055267 |
| 127. | Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL. Chem Biol. 2006 Sep;13(9):993-1000. doi: 10.1016/j.chembiol.2006.07.009. PMID: 16984889 |
| 128. | Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK. J Comb Chem. 2006 Sep-Oct;8(5):784-90. doi: 10.1021/cc050136z. PMID: 16961415 |
| 129. | Searching for new antimalarial therapeutics amongst known drugs. Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL. Chem Biol Drug Des. 2006 Jun;67(6):409-16. doi: 10.1111/j.1747-0285.2006.00391.x. PMID: 16882315 Free PMC article. |
| 130. | Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4913-6. doi: 10.1016/j.bmcl.2006.06.050. Epub 2006 Jul 24. PMID: 16860557 |
| 131. | Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. Madrid PB, Liou AP, DeRisi JL, Guy RK. J Med Chem. 2006 Jul 27;49(15):4535-43. doi: 10.1021/jm0600951. PMID: 16854059 Free PMC article. |
| 132. | A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Sci STKE. 2006 Jun 27;2006(341):pl3. doi: 10.1126/stke.3412006pl3. PMID: 16804159 |
| 133. | Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. J Comb Chem. 2006 May-Jun;8(3):315-25. doi: 10.1021/cc050142v. PMID: 16677000 |
| 134. | An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction. Mills NL, Daugherty MD, Frankel AD, Guy RK. J Am Chem Soc. 2006 Mar 22;128(11):3496-7. doi: 10.1021/ja0582051. PMID: 16536504 Free PMC article. |
| 135. | High-throughput assays for promiscuous inhibitors. Feng BY, Shelat A, Doman TN, Guy RK, Shoichet BK. Nat Chem Biol. 2005 Aug;1(3):146-8. doi: 10.1038/nchembio718. Epub 2005 Jul 3. PMID: 16408018 |
| 136. | Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. J Biol Chem. 2005 Dec 30;280(52):43048-55. doi: 10.1074/jbc.M506693200. Epub 2005 Oct 31. PMID: 16263725 |
| 137. | Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Anderson MO, Sherrill J, Madrid PB, Liou AP, Weisman JL, DeRisi JL, Guy RK. Bioorg Med Chem. 2006 Jan 15;14(2):334-43. doi: 10.1016/j.bmc.2005.08.017. Epub 2005 Oct 10. PMID: 16216519 Free PMC article. |
| 138. | A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin. Anderson MO, Shelat AA, Guy RK. J Org Chem. 2005 Jun 10;70(12):4578-84. doi: 10.1021/jo0503153. PMID: 15932292 |
| 139. | Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Cell. 2005 Feb 11;120(3):343-55. doi: 10.1016/j.cell.2005.01.024. PMID: 15707893 |
| 140. | Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. Madrid PB, Sherrill J, Liou AP, Weisman JL, Derisi JL, Guy RK. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1015-8. doi: 10.1016/j.bmcl.2004.12.037. PMID: 15686903 |
| 141. | Coregulator interactions with the thyroid hormone receptor. Moore JM, Guy RK. Mol Cell Proteomics. 2005 Apr;4(4):475-82. doi: 10.1074/mcp.R500001-MCP200. Epub 2005 Jan 18. PMID: 15657066 Review. |
| 142. | Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. PMID: 15582423 |
| 143. | The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. J Biol Chem. 2005 Mar 4;280(9):8060-8. doi: 10.1074/jbc.M407046200. Epub 2004 Nov 24. PMID: 15563469 |
| 144. | Synthesis of medium ring heterocycles using an intramolecular Heck reaction. Arnold LA, Luo W, Guy RK. Org Lett. 2004 Aug 19;6(17):3005-7. doi: 10.1021/ol0487884. PMID: 15330669 |
| 145. | Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. Madrid PB, Wilson NT, DeRisi JL, Guy RK. J Comb Chem. 2004 May-Jun;6(3):437-42. doi: 10.1021/cc0340473. PMID: 15132606 Free PMC article. |
| 146. | Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Geistlinger TR, McReynolds AC, Guy RK. Chem Biol. 2004 Feb;11(2):273-81. doi: 10.1016/j.chembiol.2004.01.016. PMID: 15123288 |
| 147. | Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. Moore JM, Galicia SJ, McReynolds AC, Nguyen NH, Scanlan TS, Guy RK. J Biol Chem. 2004 Jun 25;279(26):27584-90. doi: 10.1074/jbc.M403453200. Epub 2004 Apr 19. PMID: 15100213 |
| 148. | Gene expression as a drug discovery tool. Evans WE, Guy RK. Nat Genet. 2004 Mar;36(3):214-5. doi: 10.1038/ng0304-214. PMID: 14988717 No abstract available. |
| 149. | A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D). Fujii N, Jacobsen RB, Wood NL, Schoeniger JS, Guy RK. Bioorg Med Chem Lett. 2004 Jan 19;14(2):427-9. doi: 10.1016/j.bmcl.2003.10.043. PMID: 14698174 |
| 150. | Steroid receptor coactivator peptidomimetics. Geistlinger TR, Guy RK. Methods Enzymol. 2003;364:223-46. doi: 10.1016/s0076-6879(03)64013-9. PMID: 14631848 No abstract available. |
| 151. | Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides. Collins CJ, Schilling B, Young M, Dollinger G, Guy RK. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4023-6. doi: 10.1016/j.bmcl.2003.08.053. PMID: 14592499 |
| 152. | A selective irreversible inhibitor targeting a PDZ protein interaction domain. Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. J Am Chem Soc. 2003 Oct 8;125(40):12074-5. doi: 10.1021/ja035540l. PMID: 14518976 |
| 153. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Bioorg Med Chem. 2003 Sep 1;11(18):4113-20. doi: 10.1016/s0968-0896(03)00435-8. PMID: 12927873 |
| 154. | Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. J Biol Chem. 2003 Sep 12;278(37):35079-85. doi: 10.1074/jbc.M303098200. Epub 2003 Jun 27. PMID: 12832418 |
| 155. | Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2. Geistlinger TR, Guy RK. J Am Chem Soc. 2003 Jun 11;125(23):6852-3. doi: 10.1021/ja0348391. PMID: 12783522 |
| 156. | Role of electrostatic interactions in PDZ domain ligand recognition. Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. Biochemistry. 2003 Mar 18;42(10):2797-805. doi: 10.1021/bi027061p. PMID: 12627945 |
| 157. | A novel 2′-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. Bioconjug Chem. 2002 Sep-Oct;13(5):1093-9. doi: 10.1021/bc0200226. PMID: 12236791 |
| 158. | Investigation of the PDZ domain ligand binding site using chemically modified peptides. Novak KA, Fujii N, Guy RK. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2471-4. doi: 10.1016/s0960-894x(02)00345-1. PMID: 12161160 |
| 159. | An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1. Geistlinger TR, Guy RK. J Am Chem Soc. 2001 Feb 21;123(7):1525-6. doi: 10.1021/ja005549c. PMID: 11456738 No abstract available. |
| 160. | Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols. Herradura PS, Pendola KA, Guy RK. Org Lett. 2000 Jul 13;2(14):2019-22. doi: 10.1021/ol005832g. PMID: 10891219 |
| 161. | Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Guy RK. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7307-12. doi: 10.1073/pnas.97.13.7307. PMID: 10860995 Free PMC article. |
| 162. | MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. Dobrosotskaya I, Guy RK, James GL. J Biol Chem. 1997 Dec 12;272(50):31589-97. doi: 10.1074/jbc.272.50.31589. PMID: 9395497 |
| 163. | Taxoids: new weapons against cancer. Nicolaou KC, Guy RK, Potier P. Sci Am. 1996 Jun;274(6):94-8. doi: 10.1038/scientificamerican0696-94. PMID: 8643952 No abstract available. |
| 164. | Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou KC. Chem Biol. 1994 Oct;1(2):107-12. doi: 10.1016/1074-5521(94)90048-5. PMID: 9383378 |
| 165. | Total synthesis of taxol. Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, et al. Nature. 1994 Feb 17;367(6464):630-4. doi: 10.1038/367630a0. PMID: 7906395 |
